Targeting AGEs pathway in delayed diabetic wound healing

Introduction: Diabetic complications as peripheral neuropathy and delayed wound healing affect patient’s quality of life may lead to amputation. Several mechanisms are involved in mediating these including accumulation Advanced Glycation End Products (AGEs) the subsequent state inflammation which were investigated current study. Methos: A fixed size was induced STZ-diabetic rats effect diabetes treatment with glimepiride, α-lipoic acid pyridoxamine on levels glucose, insulin, HbA1c, AGEs, RAGE, sRAGE, TNF-α adiponectin investigated. Also latency time hotplate test quantified at different points. Results: Our results have shown that STZ a condition (elevated reduced insulin), enhanced AGEs signaling sRAGE) adiponectin), accompanied by hyperalgesia healing, while all treatments able ameliorate most effects. Conclusion: These confirm involvement diabetic suggest their possible use standard therapy for patients.